Future Health: Lung Cancer Vaccine 5 to 10 Years Away

by Seth Augenstein, Digital Reporter

cimavax2

  President Barack Obama’s visit to Cuba this month will be the first by an American president in nearly a century. The thawing relations between the two countries are expected to bring a bumper crop of famed Cuban among other imports.

Strangely enough, another eagerly anticipated product is a lung cancer vaccine some say could be a breakthrough in oncology.

kelvinleemd2

CimaVax has reportedly been in development in Cuba for 25 years, partly because lung cancer is one of the leading causes of death in the Caribbean nation.

kelvinleemd

Health reporter, Maria Dorfner spoke with Dr. Kelvin Lee from Roswell Park Cancer Institute, located in Buffalo, New York.  He says Roswell Park is finalizing an application to the FDA seeking permission to conduct a U.S. clinical trial of  the cancer vaccine and that , depending on the results from that and any subsequent studies, it would likely be 5 or more years before the drug could be widely available for patients in the U.S.   CimaVax is already an approved cancer therapy in Cuba and Peru.

kelvinleemd1

HOW IT WORKS

The injection is not like the other cancer-fighting immunotherapies being developed in hundreds of American labs, said Kelvin Lee, the chair of immunology at the Roswell Park Cancer Institute in Buffalo, N.Y.

cimavax2

 

Lee and other doctors have visited the island nation several times to meet with its Cuban developers and hear updates on their progress –and they found that the vaccine was a promising potential breakthrough.  He wrote in a post on Roswell Park’s Cancer Talk blog:

“Unlike other immunotherapies, CimaVax does not target cancer directly and it is not personalized. Rather, the vaccine targets a growth factor (EGF) necessary for the cancer to survive,” Lee said. “By targeting and effectively depleting this growth factor, the cancer starves and its progress slows, prolonging patients’ lives.”

cimavax1

The results so far show that patients’ lives were extended from six to an average of 18 months with the vaccine treatment,  but there are reports of patients treated with the vaccine living five years or more.

cimavax11

Lee and the other doctors see the possibility that the vaccine’s efficacy may translate to colon, head and neck, prostrate, breast and pancreatic cancers as well, and that CimaVax may prove effective in preventing some cancers from developing or recurring.

cimavax3

Some studies have shown promise in CimaVax, as it has cut back the EGF needed for the cancer to progress.

cimavax4

It has done this with minimal side effects, including nausea, fever and vomiting.  Survival dramatically improved in those patients with advanced Stage 3 and Stage 4 tumors, according to a Cuban study conducted in 2007.

 

cimavax7

However, the vaccine has only been administered to a few thousand people worldwide –and it is still far from FDA approval, the doctor said.

A possibility of skipping Phase I testing exists, Lee added. The FDA inspection period should end sometime this year, allowing testing to begin. Lee and the other doctors envision the vaccine’s efficacy translating over to other head and neck cancers, as well.

cimavax5

Cancer Research UK urged patience in looking to CimaCax, in a statement released last year.

cimavax8

“This research is promising but this is a small trial and we will need more trial results before we know exactly how well the vaccine works for people with lung cancer. A phase 3 trial is currently in progress in Cuba,” they said in a statement.

Obama announced the U.S. was “extending a hand of friendship” to Cuba – just 90 miles from Florida – in December 2014. The cooperation between Cuban and American doctors began in 2011 and gained momentum with New York Governor Andrew Cuomo’s trade mission to Cuba in  April 2015. Since then, the U.S. has restored up to 110 daily flights to Havana.

cimavax6

Among the critics of Obama’s March 21 visit to the island nations are Sens. Marco Rubio and Ted Cruz, both presidential hopefuls who are of Cuban descent.

 

Scientists ‘find cancer’s Achilles heel’

  • Lung cancerImage copyright SPL

Scientists believe they have discovered a way to “steer” the immune system to kill cancers.

Researchers at University College, London have developed a way of finding unique markings within a tumour – its “Achilles heel” – allowing the body to target the disease.

But the personalised method, reported in Science journal, would be expensive and has not yet been tried in patients.

Experts said the idea made sense but could be more complicated in reality.

However, the researchers, whose work was funded by Cancer Research UK, believe their discovery could form the backbone of new treatments and hope to test it in patients within two years.

They believe by analysing the DNA, they’ll be able to develop bespoke treatment.

People have tried to steer the immune system to kill tumours before, but cancer vaccines have largely flopped.

One explanation is that they are training the body’s own defences to go after the wrong target.

The problem is cancers are not made up of identical cells – they are a heavily mutated, genetic mess and samples at different sites within a tumour can look and behave very differently.

‘Exciting’

They grow a bit like a tree with core “trunk” mutations, but then mutations that branch off in all directions. It is known as cancer heterogeneity.

The international study developed a way of discovering the “trunk” mutations that change antigens – the proteins that stick out from the surface of cancer cells.

Professor Charles Swanton, from the UCL Cancer Institute, added: “This is exciting. Now we can prioritise and target tumour antigens that are present in every cell – the Achilles heel of these highly complex cancers.

“This is really fascinating and takes personalised medicine to its absolute limit, where each patient would have a unique, bespoke treatment.”

There are two approaches being suggested for targeting the trunk mutations.

The first is to develop cancer vaccines for each patient that train the immune system to spot them.

The second is to “fish” for immune cells that already target those mutations and swell their numbers in the lab, and then put them back into the body.

‘Early days’

Dr Marco Gerlinger, from the Institute of Cancer Research, said: “This is a very important step and makes us think about heterogeneity as a problem and why this gives cancer this big advantage.

“Targeting trunk mutations makes sense from many points of view, but it is early days and whether it’s that simple, I’m not entirely sure.

“Many cancers are not standing still but they keep evolving constantly. These are moving targets which makes it difficult to get them under control.

“Cancers that can change and evolve could lose the initial antigen or maybe come up with smokescreens of other good antigens so that the immune system gets confused.”


Analysis

James Gallagher, health editor, BBC News website

Harnessing the power of the immune system – what’s known as immunotherapy – is the most exciting field in cancer and probably in all of medicine right now.

But while that excitement is justified, claims that a cure for cancer is around the corner are not.

Medical research is littered with the graves of hyped treatments that just never worked.

Two decades ago, gene therapy was “hype-central” and we’re still waiting for it to transform medicine.

This study demonstrates some spectacular science that furthers understanding of how the immune system and cancer interact.

But this new knowledge has not been used to treat a single patient. There have not even been animal studies. So there is a real risk it will not work.

Even if it does, this is an hugely expensive approach that would need to be customised to every patient in a process that takes more than a year from start to finish.


Some immunotherapy treatments work spectacularly with some patients’ cancer disappearing entirely.

They take the brakes off the immune system, freeing it up to fight cancer.

The researchers hope the combination of removing the immune system’s brakes and then taking over the steering wheel, will save lives.

Professor Peter Johnson, from Cancer Research UK, said the research had shown “impressive results in the clinic” and although “the technology is complicated and quite recent… once you start doing it the cost will come down”.

‘Elegant study’

Dr Stefan Symeonides, clinician scientist in experimental cancer medicine at the University of Edinburgh, said designing a personalised vaccine was currently impractical, especially when a patient needed treatment straight away.

But he added that the “very elegant” study did provide a ground-breaking insight into current immunotherapy drugs, which do not yet work for most people.

“It’s not just the number of antigens, it’s how many of the cancer cells have them,” he said.

“This data will be quoted in discussions for years, as we try to understand which patients benefit from immunotherapy drugs, which ones don’t, and why, so we can improve those therapies.”

Follow James on Twitter.

Must Read: 5 Hottest Tips to Prevent and Treat Cancer

If you read one article on cancer prevention and treatment prior to seeing a doctor, this is it.    -Maria Dorfner

 

About the Guest Author:  Gary Hyman, MD is Director at the Cleveland Clinic Center for Functional Medicine, The UltraWellness Center and The Institute for Functional Medicine

A Functional Medicine Approach to Cancer by Gary Hyman, MD

                                                                     

Functional medicine empowers patients and practitioners to achieve the highest expression of health by working collaboratively to address the root causes of disease. It is an emerging, personalized model of diagnosis and treatment that better addresses the need to prevent and manage chronic disease. In a word, it is the medicine of WHY, not WHAT.

Functional Medicine doctors are like soil farmers. They create a healthy soil, so pests can’t come and weeds can’t flourish. A healthy soil means disease can’t take hold.

So with cancer, a Functional Medicine practitioner would say that yes, we still need radiation and other conventional approaches, but what else can we do? How can we properly cultivate a healthy soil?

Cancer results because of in an imbalance in the system. So many people are walking around with tumors and don’t know it. We can do something to prevent them from growing by maintaining a healthy soil.

Instead of dividing everything into diseases and labels, emerging science points to a different way of thinking about diseases. Rather than divide the body into organs, Functional Medicine approaches disease as a systemic problem, and we have to treat the system, not the symptom; the cause, not the disease. This completely redefines the whole notion of disease. The landscape of illness is changing.

How we label cancer is no longer synced up with what we know about the origins of cancer or the fact that two people who have cancer with the same name—like breast cancer—can have two completely different diseases which require different treatments. Just because you know the name of your disease doesn’t mean you know what’s wrong with you or what to do about it.

Classifying tumors by body site — lung, liver, brain, breast, colon, etc. — misses the underlying causes, mechanisms, and pathways involved in a particular cancer. What’s more, it gives us no information about how it manifested in a given patient. Two people with cancers in different parts of the body may have developed it for the same reasons.

Similarly, two people with cancers in the same part of the body may have developed it for different reasons. A patient with prostate cancer and one with colon cancer may have more in common with each other than two patients who have colon cancer.

We need to look under the hood and find out what caused the illness to begin with.

Cultivating a Healthy Soil

Numerous things can contribute to cancer. Studies show diet, exercise, thoughts, feelings, and environmental toxins all influence the initiation, growth, and progression of cancer.

If a nutrient-poor diet full of sugar, lack of exercise, chronic stress, persistent pollutants, and heavy metals can cause cancer, could it be that a nutrient-dense, plant-based diet, physical activity,changing thoughts and reactions to stress, and detoxification might treat the garden in which cancer grows?

In other words, treat the soil, not the plant. It is a foundational principle of sustainable agriculture, and of sustainable health.

We can enhance immune function and surveillance through dietary and lifestyle changes, as well as nutrient and phytonutrient therapies. We can facilitate our body’s own detoxification system to promote the elimination of carcinogenic compounds. We can improve hormone metabolism and reduce the carcinogenic effects of too much insulin (more on that in a minute) from our high sugar and refined carbohydrate diet.

We can also alter how our genes are expressed by changing the inputs that control that expression: Diet, nutrients, phytonutrients, toxins, stress, and other sources of inflammation. And we can focus on less divisive and more generative thoughts that, in turn, create more uplifting emotions — all good fertilizer for the soil in the garden of our body.

The Number One Thing You Can Do to Prevent or Control Cancer

Diabesity, the continuum of health problems ranging from mild insulin resistance and overweight to obesity and diabetes, is the single biggest global health epidemic of our time. It is one of the leading causes of heart disease, dementia, cancer, and premature death in the world and is almost entirely caused by environmental and lifestyle factors.

This means that it is almost 100 percent preventable and curable.

Diabesity affects over 1.7 billion people worldwide. Scientists conservatively estimate it will affect one in two Americans by 2020; 90 percent of whom will not be diagnosed.

Obesity (almost always related to diabesity) is the leading cause of preventable death in the United States and around the world. The link between obesity and cancer is well documented and is driven by insulin resistance. Insulin, the fat storage hormone, also drives more inflammation, oxidative stress, and a myriad of downstream effects including high blood pressure, high cholesterol, low HDL, high triglycerides, poor sex drive, infertility, thickening of the blood, and increased risk of cancer, Alzheimer’s, and depression.

The best thing you can do to prevent or control cancer is to control insulin levels with a high-fiber diet rich in real, fresh, whole foods and minimize or eliminate sugary, processed, insulin-raising foods.

Dr. Dean Ornish showed that after just three months on an intensive lifestyle program including a whole-foods, plant-based diet, over 500 genes that regulate cancer were beneficially affected, either turning off the cancer-causing genes or turning on the cancer-protective genes. No medication can do that.

5 Strategies to Reduce Cancer Formation and Growth

Cancer results from an imbalance in our system where the immune system can’t fight off tumors. We can do many things to prevent that cancer from getting to its full stage, and if you have cancer, you can make your body inhospitable to that cancer.

1.

Eliminate food sensitivities. In a major study in the Journal of the American Medical Association, hidden gluten sensitivity was shown to increase risk of death by 35 to 75 percent, mostly by causing heart disease and cancer. By just this mechanism alone, more than 20 million Americans are at risk for heart attack, obesity, cancer, and death. Dairy and gluten are the most common triggers of food allergies that are linked to insulin resistance. Cutting them out of the diet allows the inflamed gut and an inflamed body to heal.

2.

Reduce inflammation. Inflammation is the common thread connecting most chronic disease including cancer. In fact, out-of-control inflammation causes insulin resistance, which, as we now know, is the main factor in all these diseases apart from autoimmunity and allergy. The insulin resistance then creates even more inflammation, and the whole biological house burns down. Besides removing sugar and food sensitivities like gluten and dairy, we want to eat plenty of anti-inflammatory foods, including omega-3 rich foods like wild fish and flaxseeds.

3.

Improve gut health. Cancer often originates in your gut. Not just colon cancer, but with many cancers. We are currently studying about the gut microbiome and breast and prostate cancers. Beyond avoiding inflammatory foods, adding in probiotics, prebiotics, and lots of phytonutrients, like curcumin (found in turmeric) and resveratrol (found in grapes), can reduce gut-based inflammation.

4.

Reduce toxic exposure. The average newborn has 287 chemicals in her umbilical cord blood, 217 of which are neurotoxic (poisonous to nerves or nerve cells). The chemicals these infants are exposed to include pesticides, phthalates, bisphenol A, flame retardants, and heavy metals such as mercury, lead, and arsenic. These chemicals have a broad range of negative effects on human biology; they damage the nervous system and increase the risk of cancer, and now they have been shown to contribute to obesity. Going clean and green means becoming more aware about how environmental toxins affect your health. I encourage you to visit the Environmental Working Group (EWG) to learn more.

5.

Change your thoughts to change your immune system. Science is now proving what we all knew intuitively — that how we live, the quality of our relationships, the food we eat, and how we use our bodies determines much more than our genes ever will. There are numerous strategies to combat or prevent cancer, including getting sufficient sleep, controlling stress levels, and exercising regularly.

The important thing is to figure out what works for you and develop a plan to stick with it. That might involve working with a Functional Medicine doctor or a chronic disease specialist.

Conclusion

Whether you have been diagnosed with cancer or have become concerned about family and friends being diagnosed, the most important thing is mindset and not playing into fear.

While we all hope there will one day be a miracle cure for cancer, there are things that we know now will combat cancer or keep our quality of life high while our body is fighting the cancer.

The science of cancer genetics is changing. Two people who have the same cancer could be completely different in terms of how the cancer performs. That’s why I’m very excited about the work that Dr. Patrick Soon-Shiong is doing in California on the cancer genome and creating targeted therapies to treat the cancer in every patient individually. This and other emerging technologies, combined with the Functional Medicine approach to cancer, give me great hope about our ability to further prevent and treat this disease in the future.

I encourage you to think about cancer differently and more importantly, not lose hope.

Stay healthy, everyone! -Maria

MARIADORFNERBLACKANDWHITEHEADSHOT    Maria Dorfner (formerly Pallante Bianco) is the founder of MedCrunch, covering What’s Hot in Health.

At 24, she helped launch CNBC after working full-time at NBC for two years and part-time throughout college. She then joined Ailes Communications as director of research and producer for TV pilots successfully syndicated. She then co-anchored and senior produced several health series airing on CNBC for three years. She wrote, produced and directed medical documentaries for Discovery Health Channel and helped launch the Cleveland Clinic News Service.  She is the owner of NewsMD Communications, a full-service production company specializing in health content and distribution. She is the author of three books.  Her awards include an Outstanding Leadership Abilities and Commitment to the Advancement of Women in Media award from her alma mater and a Media Recognition Award from the American Heart Association for her “Heart Smart” series and a Medical Reporting Scholarship. Maria is in Who’s Who in American Women, 22nd edition, 2000/2001.  She is a native of Brooklyn, New York.  Her health blog is a division of Healthy Within Network, which is her existing labor of love.  It connects the dots in medicine, media and marketing.  Contact:  maria.dorfner@yahoo.com

Hottest Health Career of the Future by Maria Dorfner

billing14

If your kids are graduating from college wondering what to do with the rest of their lives, and they’re interested in the health field, but avoid it to make more money elsewhere, keep reading.  If not, keep reading anyway!  Thank you.

Today, “kids” are encouraged to be entrepreneurs. Start a company at the age of 3!

All before they EVEN know what to do with money (reminds me of a blog Brian Cuban wrote about why sports figures or celebs  end up broke). I think the future is going to include founders. How many “founders” are there today and where will they be in 20 years?

I understand why it’s happening.  You get fired up every time you read about a dumb idea getting millions of dollars in funding. It’s frustrating because you think your ideas are FAR BETTER.

Those articles encourage kids to quit their jobs or not attend college at all.   The unhealthy message they get is just come up with the next great thing, get funded and you’ll be fine.

Really?

Let’s peak behind-the-scenes. Some crappy idea getting millions in investments may be one college buddy who is now a VC helping another college buddy. No intention to “save the world” which a lot use as their mission statement. That buddy VC attracts others, who have no idea they are going to lose money because it was just a gift to a friend, and not a real investment in anything real. The Nancy Drew in me can spot scams before they become public.   We need a delete/block in life for folks who try to take advantage or exploit others.  Lots of snake oil salesmen out there feeding off of hungry entrepreneurs.

There’s also other little factors you can’t control. So, your idea being better means nothing.

NADA.

Additionally, even if it’s legitimate, the majority of those companies will fail. Proven fact. Even if you get funding, expect to work your you know what off for one VERY expensive lesson.

I digress.  Back to HOTTEST HEALTH CAREER of the FUTURE.

billing14

If you REALLY want to change the world and have an interest in health –take a look at the future and where there will be ACTUAL demand.

HERE’S A GLIMPSE through my eyes.  My parents always say, “Maria has a big heart.” So, if eyes are the windows of the soul…my green peeps would be shaped like this. 

hearteye

They’re not, but thanks to the San Diego Eye Institute my vision is 20/20 to see the future:

FUTURE IN HEALTH CAREERS:

20% of all U.S. physicians are 55 or older, including more than HALF of the 5,000 active board-certified thoracic surgeons. Approximately 70% are expected to retire in the next 13 years, dramatically shrinking the provider pool leading to a critical work shortage JUST when aging baby boomers are sick and tired of stomping on grapes.   

lucy1

Most of these sick baby boomers will suffer from heart disease creating quite a demand for well-trained heart surgeons, even if that surgeon is in another room or at home while doing this robotic or digital surgery.  In real estate they say, Location, Location, Location.   When it comes to a career in health, I say it’s

DEMAND. DEMAND. DEMAND.

billing6

By 2025, some experts predict the number will be almost 2,000 short of what’s needed in the U.S. The demand for heart surgeons will explode. They battle both heart disease AND lung cancer –another baby boomer problemo. 

Average starting salary for a heart /lung surgeon? 350K

westshoreinn12

That’s right. Your kid makes 350K right out of college.  CA-CHING!

How long do they need to study? Residency required is 5 years followed by 2 fellowship years. You may work 50 hours a week, but you’ll do that if you’re entrepreneur too. Only you’re creating crazy things in the HOPES of creating demand.

Even if there IS a demand, you HAVE to convince friends, family or PWM (People. With. Money) you haven’t lost your marbles.  Does the product or service create the demand or vice versa?  I say when people need something it’s subconscious. When it shows up, they recognize it because the need (demand) was already there. It does NOT exist first.  I aced marketing in college with one other person. That tells me 2 out 10 people in a room understand.  The other 8 wait to “see” something first.   They lack vision.

lowerestogen-300x207

Now, let’s look at a man with all his marbles AND vision in tact. He is one of the best cardiothoracic surgeons in the world.   I say THE best.  His name is Delos “Toby” M. Cosgrove. I am honored to call Mr. and Mrs. Cosgrove friends. When I first met them in 2001, Toby was Chief Cardiothoracic Surgeon at the Cleveland Clinic.

Today, he is Chairman. Under his leadership, the Cleveland Clinic’s heart program is consistently ranked NUMERO UNO. He presides over the $6B healthcare system that is The Cleveland Clinic. Calling him an innovator is also an understatement. He holds 30 patents and is absolutely brilliant.

ccf4

I spoke with Toby about what it takes to be a resident at the #1 heart program and will share that later.

I followed him and went behind-the-scenes as he interviewed the best and brightest students to be selected for a residency at The Cleveland Clinic. Since it’s ranked #1, it attracts the smartest students from around the world. Interestingly enough, there was only one woman in the group. In general, 66% of physicians are male. Only 29% are female. Another shortage and demand for the future.

Tie this with the current obesity epidemic, a leading cause of heart disease.

ccf6

Most recently, Cosgrove warned people about the link between heart disease connected to the foods you eat. You know when a man who would profit from your heart disease issues a warning –it’s time to listen.

ccf3

May 2, 2013 How Our Guts – and What We Eat – Contribute to Heart Disease, Stroke and the National Debt

by Delos M. Cosgrove

We’re gorging ourselves into an epidemic of chronic disease, the costs of which will soon overwhelm our ability to pay and continue to be a contributing factor to the ever-increasing national debt. More proof of this has emerged with two studies that have uncovered new links between common foods and heart disease, stroke and death.

The culprit is a little-known substance called TMAO, or trimethylamine-N-oxide. It’s created when bacteria in the gut interact with two specific dietary nutrients – carnitine (found in red meat and dairy products) and lecithin (found in egg yolks, liver, beef, pork and wheat germ).

We now know that TMAO helps fatty substances in the blood to accumulate in the walls of the coronary arteries. These accumulations, called plaques, are the frequent cause of chest pains and heart attacks.

These findings were made in two recent studies by researchers in the Cleveland Clinic Lerner Research Institute and reported in the New England Journal of Medicine and Nature Medicine. It’s interesting to note the usual bad guy in heart disease, dietary fat, is not the person of interest here. Carnitine, the substance that gut bacteria convert into TMAO, is not in the fatty part of the meat. It’s in the red, meaty part. So it doesn’t matter if you cut the fat off your steak, or if you buy lean cuts.

So there’s no getting away from it. We have to be more careful about what we put in our mouths. We need to be aware of the foods that contain high amounts of carnitine and lecithin. But the real message of this research is broader – each person’s unique gut flora has a tremendous impact in how our bodies react to these nutrients. Those with TMAO levels among the top 25 percent had 2.5 times the risk of a heart attack or stroke compared to people in the bottom 25 percent.

Such a finding could change the way we prevent and treat heart disease, by using TMAO blood levels as a marker of cardiovascular risk and possibly a treatment target.

No one is suggesting the complete elimination of red meat and egg yolk from your diet. Like so much in life, moderation is key. You can continue to enjoy a good steak, but you may want to limit it to about 4 to 6 ounces every other week.

We’re facing an avalanche of chronic disease in the coming years. Anything we can do to mitigate this avalanche of heart disease — and other chronic conditions like cancer and diabetes — will not only give us longer and happier lives, it will improve the economic outlook for our children and grandchildren who will ultimately have to pay for our poor lifestyle choices.

ccf8
______________________________________________________________________________________________________________

Here is another interesting finding:

According to the U.S. Census Bureau, as of 2010, there were over 850K licensed physicians in the United States. In the United States, there are approximately 24,000 physicians for every 10,000 people.

I wanted to find out how many physicians per people there were in the healthiest countries. Turns out, the average is 34.9 physicians for every 10,000 people.

So, the shortage isn’t just in the field of cardiovascular surgery. I am a HUGE fan of preventing disease instead of treating it. Will we no longer need physicians or surgeons if we are able to prevent disease?

Too late. Even if you are healthy today, you still exposed an inordinate amount of toxins in the environment AND stress caused by factors you can’t control. Staying healthy involves continually being educated on what toxins to avoid AND learning and relearning healthy strategies and HOW to remain calm in the face of adversity.

There is A LOT of adversity in the world.   Enough to make you sick.

So, any disease that exists now or in the future has already been created and needs to either be REVERSED or TREATED. It will take as long as it did to create this disease to rid it from the existing population in the world. The only people who can completely benefit from PREVENTION are those who are A) already healthy or B) newborns.

And these two groups still need to be consistently educated on prevention from people like Delos M. Cosgrove.

So, if you’re smart and want to help change the world, it’s a field that will have an opening for you when you graduate with a good starting salary.

Of course, I know everyone isn’t “cut” out to be a heart surgeon or can be.  All I’m saying is if you CAN, do it.  The only question is do you have the academic grades for it? If yes, you can find financial resources.  If you don’t have the grades for it or it’s too late to select this field –then encourage a smart kid to explore it as a career.

I know recent college grads who make between $7 to $15 an hour or $20K, which was the starting salary THIRTY years ago AND the economy was thriving then. So, if you or your kid is smart –think longterm.

You need patience to be an entrepreneur OR a heart surgeon.  The latter guarantees success & innovation as dexterity is now a criterion as robotics and computers enter operating rooms. Think of it as fun playing video games while saving lives.

ccf5

More importantly, it’s a career with HEART that won’t have you screaming, “I can’t take it anymore!” at the end.

movie30

p.s.  I was a founder before it was cool or part of a herd mentality.

__________________________________________________________________________________________________________

Speaking of leaders, be sure to FOLLOW DELOS M. COSGROVE as a THOUGHT LEADER on Linked In.

Cleveland Clinic: http://my.clevelandclinic.org/staff_directory/default.aspx

billing18

Click FOLLOW button on upper-right-hand corner of this blog to be alerted by email when there’s a new post, thanks.

First Non-Invasive Imaging to Detect Brain Tumors

Diagnostic Brain Tumor Test Could Revolutionize Care of Patients with Low-Grade Gliomas

Researchers at UT Southwestern Medical Center have developed what they believe to be the first clinical application of a new imaging technique to diagnose brain tumors. The unique test could preclude the need for surgery in patients whose tumors are located in areas of the brain too dangerous to biopsy.

This new magnetic resonance spectroscopy (MRS) technique provides a definitive diagnosis of cancer based on imaging of a protein associated with a mutated gene found in 80 percent of low- and intermediate-grade gliomas. Presence of the mutation also means a better prognosis.

“To our knowledge, this is the only direct metabolic consequence of a genetic mutation in a cancer cell that can be identified through noninvasive imaging,” said Dr. Elizabeth Maher, associate professor of internal medicine and neurology at UT Southwestern and senior author of the study, available online in Nature Medicine. “This is a major breakthrough for brain tumor patients.”

UT Southwestern researchers developed the test by modifying the settings of a magnetic resonance imaging (MRI) scanner to track the protein’s levels. The data acquisition and analysis procedure was developed by study lead author Dr. Changho Choi, associate professor of the Advanced Imaging Research Center (AIRC) and radiology. Previous research linked high levels of this protein to the mutation, and UT Southwestern researchers already had been working on MRS of gliomas to find tumor biomarkers.

“Our next step is to make this testing procedure widely available as part of routine MRIs for brain tumors. It doesn’t require any injections or special equipment,” said Dr. Maher, medical director of UT Southwestern’s neuro-oncology program.

To substantiate the test as a diagnostic tool, biopsy samples from 30 glioma patients enrolled in the UT Southwestern clinical trial were analyzed; half had the mutation and expected high levels of the protein. MRS imaging of these patients had been done before surgery and predicted, with 100 percent accuracy, which patients had the mutation.

For Thomas Smith of Grand Prairie, the test helped determine the best time to begin chemotherapy. When an MRS scan showed a sharp rise in the 25-year-old’s protein levels, this indicated to his health care team that his tumor was moving from dormancy to rapid growth.

“We treated him with chemotherapy and his protein levels came down,” Dr. Maher said.

Before participating in the study, Mr. Smith had tumor removal surgery in 2007. Because part of the tumor could not be safely removed, however, he continued to suffer seizures and had other neurological problems. Since chemotherapy, his symptoms have diminished.

“I did six rounds of chemo, every six weeks,” Mr. Smith said. “My seizures stopped and all my symptoms improved. I am only on anti-seizure medication now.”

Notes about this brain cancer research article

Other UT Southwestern researchers involved in the study included Sandeep Ganji, a doctorate student in radiological sciences; Dr. Ralph DeBerardinis, assistant professor of pediatrics and with the Eugene McDermott Center for Human Growth and Development; Dr. Kimmo Hatanpaa, associate professor of pathology; Dr. Dinesh Rakheja, assistant professor of pathology; Dr. Zoltan Kovacs, assistant professor in the AIRC; Drs. Xiao-Li Yang and Tomoyuki Mashimo, both senior research scientists in internal medicine; Dr. Jack Raisanen, professor of pathology; Dr. Isaac Marin-Valencia, resident in pediatrics; Dr. Juan Pascual, assistant professor of neurology and neurotherapeutics, pediatrics, and physiology; Dr. Christopher Madden, associate professor of neurological surgery; Dr. Bruce Mickey, professor of neurological surgery and otolaryngology-head and neck surgery, and radiation oncology; Dr. Craig Malloy, professor in the AIRC and of internal medicine and radiology; and Dr. Robert Bachoo, assistant professor in neurology and neurotherapeutics, and internal medicine.

Funding: The research was supported by grants from the National Institutes of Health, the Cancer Prevention and Research Institute of Texas and financial support from the Annette G. Strauss Center for Neuro-oncology at UT Southwestern.

National Brain Tumor Society Logo
Image via Wikipedia

Contact: Debbie Bolles – The University of Texas Southwestern Medical Center
Source: The University of Texas Southwestern Medical Center press release
Original Research: Abstract for “2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas” by Changho Choi, Sandeep K Ganji, Ralph J DeBerardinis, Kimmo J Hatanpaa, Dinesh Rakheja, Zoltan Kovacs, Xiao-Li Yang, Tomoyuki Mashimo, Jack M Raisanen, Isaac Marin-Valencia, Juan M Pascual, Christopher J Madden, Bruce E Mickey, Craig M Malloy, Robert M Bachoo and Elizabeth A Maher from Nature Medicine

 Also See Link Below: Novel Drug Makes Brain Tumors Glow Hot Pink

Related Neuroscience Articles

UT Southwestern
Image via Wikipedia

Meet The Chief Wellness Officer at The Cleveland Clinic: Dr. Michael Roizen

By Janet Podolak

 

Drinking milk can cause cancer.

Cheap yellow mustard may prevent Alzheimer’s disease.

Heavy cardio workouts can reverse Parkinson’s disease.

MichaelRoizen

These statements by Dr. Michael Roizen caused his audience to sit up and take notice. Folks were attending a Healthy Foods class hosted in Chester Township by Loretta Paganini.

michaelroizen1

The chief wellness officer at Cleveland Clinic, Roizen believes that diet, exercise and lifestyle changes can reverse health problems, even those inherited as part of family history.

michaelroizen6.jpg

 

“We’re at our peak around 30, and it’s downhill from there,” he told the 80-person group gathered at the International Culinary Arts & Sciences Institute. He said a Harvard study by doctors confirms the loss of 5 percent of mental and physical function every 10 years after age 30. But that’s not inevitable, he said.

“After 30, it’s choices that make those determinations, and the food you eat can turn on good genes and turn off bad ones,” he said.

michaelroizen5

A researcher whose work as an author and speaker commands widespread attention, Roizen says he loves what he does — and that loving what you do is one of his secrets to a longer, healthier life.

nutrition1

“Dr. Roizen has changed the character of the Cleveland Clinic and has made believers out of people like me,” said Dr. Emil Paganini, a retired nephrologist at the clinic who has joined his wife’s Chester Township culinary operation along with doing medical consultation work. He gained 80 pounds after adopting a more sedentary lifestyle, but in the past six months has shed 50 pounds and increased his stamina and muscle tone with diet and exercise

“Anyone can do it,” Roizen told the group.

michaelroizen3

He’s personally delivered health care to eight Nobel Prize winners, 700 former smokers and more than 100 Fortune 500 CEOs.

michaelroizen2

“Your genes make protein, and with healthy eating you can change them,” he said, beginning a slide presentation showing before-and-after photos of a man who followed Roizen’s better health protocol for 28 days. The 50-something diabetic’s health was so bad he was verging on a stroke.

cdc14

“In just 28 days he lost weight, brought his blood sugar down from 175 to 99, and nearly normalized his blood pressure,” Roizen said. “To do that, he quit smoking, gave up meat and animal products, did 15 minutes of meditation morning and evening, and walked 10,000 steps a day.”

walking

Roizen doesn’t claim the protocol is easy but says it’s life-saving.

Trainer Jaime Brenkus, who is based at Slim & Fit Personal Weight Loss and Fitness in Concord Township, says the resolve for true change is motivated by one of two things.

health6

“Motivation comes from either the desire to change one’s image or a combination of pain and fear,” Brenkus said.

He works with the Paganini family members on their own fitness goals and said he came to Roizen’s presentation in search of information and inspiration.

roizenbook2

Roizen, who regularly reviews clinical trials and other professional findings, is perhaps best-known for his “RealAge” books about turning back the biological clock, and the “YOU” series authored with colleague Dr. Mehmet Oz.

He researches in real-life scenarios, such as spending time at a call center where, he said, the daily stress level is 22 times higher than in daily life.

stress

Reducing stress is a key component to any health plan, and exercise and meditation are just part of the answer, he said. He said loving what you do and having supportive friends are just as important.

michaelroizen17

“The whole obesity epidemic began in the 1980s when we got the idea that it’s OK to eat anything, anytime, anywhere,” he said. “But good health isn’t ‘Let’s Make a Deal.’ There are things we just should not eat.”

soda1

The theory that “just a little” of a forbidden food won’t do any harm is a fallacy, he said.

“One ounce of Pepsi is not going to hurt, but who do you know who can stop with one ounce?” he said.

healthy

He has a similar reaction to news that wine can be good for you.

“Alcohol can be good for the blood but is bad for the immune system,” he said. “And with 17 percent of drinkers ending up with addiction, it just doesn’t make sense to start drinking if you don’t drink.”

foodcomaHe said sugar, which can be addictive because it releases “feel-good” dopamine into the body just as heroin and cocaine do, is one of those substances best eliminated.

“High levels of blood sugar that result in diabetes cause the same lesions on the brain as Alzheimer’s does. So avoiding added sugars is critical for health.”

foodcoma1

The damage caused by saturated and trans fats has been proved, he said.

“That means no french fries,” he said, noting deep fryers have been eliminated at Cleveland Clinic. “We now have 48 of them for sale.”

WALK2

Walking 10,000 steps a day measured by a pedometer is a behavior to embrace, he said.

“Ten thousand steps is the point at which sugars in the blood are converted,” he said. “Not 7,000, not 12,000, but 10,000 steps every day.”

exercise1

Hard physical exercise — 21 minutes at least three times a week — has been shown to improve memory function in addition to fitness levels.

exercise4

A surprise finding came from a bicycle competition in which Parkinson’s patients were on the rear of tandem bikes pedaled by athletes.

bikeriding1

“We discovered that 30 minutes of vigorous exercise three times a week led to a remission of Parkinson’s in 70 percent of them,” Roizen said.

And as for his “cheap mustard” statement regarding Alzheimer’s?

“Cheap yellow mustard is loaded with turmeric instead of mustard seed,” he said. “Everything eaten in India is made with turmeric, and there’s a zero rate of Alzheimer’s there.”

healthy1

 

Roizen’s tips for improved health

Eliminate:

— Added sugar

— Added corn syrup

— Simple carbohydrates found in most flours

— Saturated fats

— Trans fats

— Dairy products including cheese

Add:

— 900 milligrams DHA, found in omega 3, preferably from algae

— 1,200 milligrams Vitamin D3

— 600 milligrams calcium with magnesium

— Probiotics

— 2 baby aspirin taken with warm water.

Behaviors to embrace:

— Floss teeth

— Sleep 61⁄2 to 8 hours a day

— Know your blood pressure and strive for 115 over 75

— Have a buddy for workouts

— Learn to like black coffee and soy milk

— Find something you love and do it every day.

michaelroizen10

Excellent advice.  It’s no wonder that in 2007, Dr. Roizen was named Chief Wellness Officer at Cleveland Clinic, a world-class leader in medicine, research, education, technology and innovation. It is the first such position in a major healthcare institution in the United States.

michaelroizen14

For More Information on the Cleveland Clinic Wellness visit:

http://www.myclevelandclinic.org/wellness.com

And be sure to check out all of Dr. Roizen’s amazing books on Amazon at:

https://www.amazon.com/s/ref=nb_sb_ss_c_0_14?url=search-alias%3Dstripbooks&field-keywords=michael+roizen&sprefix=michael+roizen%2Caps%2C299

They include:

 

roizenbook2     roizenbook1

 

ccf9

 

healthy1

Stay healthy!

MARIA DORFNER  is founder of NewsMD and Healthy Within Network. This is her blog.

She can be reached at maria.dorfner@yahoo.com and on Twitter: Maria_Dorfner